Team Publications


NSBRI encourages and expects its funded investigators to publish findings of their research in scholarly, peer-reviewed journals. Below is a comprehensive list of publications for the Human Factors and Performance Team since the Institute's inception in 1997.  

Aguzzi J, Bullock NM, Tosini G.  Spontaneous internal desynchronization of locomotor activity and body temperature rhythms from plasma melatonin rhythm in rats exposed to constant dim light.  J Circadian Rhythms 4(1):6, 2006.  PMID: 16594995

Åkerstedt T, Wright KP Jr.  Sleep loss and fatique in shift work and shift work disorder.  Sleep Med Clin. 2009 Jun;4(2):257-71.  PMID: 20640236

Anderson JL, Glod CA, Dai J, Cao Y, Lockley SW.  Lux vs. wavelength in light treatment of Seasonal Affective Disorder.  Acta Psychiatr Scand. 2009 Feb; 120: 203–212. 
PMID: 19207131

Apanasovich TV, Ruppert D, Lupton JR, Popovic N, Turner ND, Chapkin RS, Carroll RJ.  Aberrant crypt foci and semiparametric modeling of correlated binary data.  Biometrics. 2008 Jun;64(2):490-500.  PMID: 17725810

Apanasovich TV, Sheather S, Lupton JR, Popovic N, Turner ND, Chapkin RS, Braby LA, Carroll RJ.  Testing for spatial correlation in nonstationary binary data, with application to aberrant crypt foci in colon carcinogenesis.  Biometrics. 2003 Dec;59(4):752-61.  PMID: 14969452

Ayas NT, Barger LK, Cade BE, Hashimoto DM, Rosner B, Cronin JW, Speizer FE, Czeisler CA.  Extended work duration and the risk of self-reported percutaneous injuries in interns.  JAMA. 2006 Sep 6;296(9):1055-62.  PMID: 16954484

Bajaj A, Rosner B, Lockley SW, Schernhammer ES. Validation of a light questionnaire with real-life photopic illuminance measurements: The Harvard Light Exposure Assessment questionnaire. Cancer Epidemiol Biomarkers Prev., 20 (7):1341-1349, 2011.

Baladandayuthapani V, Mallick BK, Young Hong M, Lupton JR, Turner ND, Carroll RJ.  Bayesian hierarchical spatially correlated functional data analysis with application to colon carcinogenesis.  Biometrics. 2008 Mar;64(1):64-73.  PMID: 17608780

Bancroft LK, Lupton JR, Davidson LA, Taddeo SS, Murphy ME, Carroll RJ, Chapkin RS.  Dietary fish oil reduces oxidative DNA damage in rat colonocytes.  Free Radic Biol Med. 2003 Jul 15;35(2):149-59.  PMID: 12853071

Banks S, Dinges DF.  Behavioral and physiological consequences of sleep restriction.  J Clin Sleep Med. 2007 Aug 15;3(5):519-28.  PMID: 17803017

Banks S, Van Dongen HP, Maislin G, Dinges DF.  Neurobehavioral dynamics following chronic sleep restriction: dose-response effects of one night for recovery.  Sleep. 2010 Aug 01; 33(8):1013-1026.  PMID: 20815182

Barger LK, Cade BE, Ayas NT, Cronin JW, Rosner B, Speizer FE, Czeisler CA.  Extended work shifts and the risk of motor vehicle crashes among interns.  N Engl J Med. 2005 Jan 13;352(2):125-34.  PMID: 15647575

Barger LK, Wright KP Jr, Hughes RJ, Czeisler CA.  Daily exercise facilitates phase delays of circadian melatonin rhythm in very dim light.  Am J Physiol Regul Integr Comp Physiol. 2004 Jun;286(6):R1077-84.  PMID: 15031136

Barnard AR, Appleford JM, Sekaran S, Chinthapalli K, Jenkins A, Seeliger M, Biel M, Humphries P, Douglas RH, Wenzel A, Foster RG, Hankins MW, Lucas RJ.  Residual photosensitivity in mice lacking both rod opsin and cone photoreceptor cyclic nucleotide gated channel 3 alpha subunit.  Vis Neurosci. 2004 Sep-Oct;21(5):675-83.  PMID: 15683556

Basner M, Dinges DF.  Dubious bargain: trading sleep for Leno and Letterman.  Sleep. 2009 Jun 1;32(6):747-52.  PMID: 19544750

Basner M, Fomberstein KM, Razavi FM, Banks S, William JH, Rosa RR, Dinges DF.  American Time Use Survey: sleep time and its relationship to waking activities.  Sleep. 2007 Sep 1;30(9):1085-95.  PMID: 17910380

Børsheim E, Bui QU, Tissier S, Kobayashi H, Ferrando AA, Wolfe RR.  Effect of amino acid supplementation on muscle mass, strength and physical function in elderly.  Clin Nutr. 2008 Apr;27(2):189-95.  PMID: 18294740

Brainard GC, Hanifin JP.  Photons, clocks, and consciousness.  J Biol Rhythms. 2005 Aug;20(4):314-25.  PMID: 16077151

Brainard GC, Hanifin JP, Greeson JM, Byrne B, Glickman G, Gerner E, Rollag MD.  Action spectrum for melatonin regulation in humans:  evidence for a novel circadian photoreceptor. J Neurosci. 2001 Aug 15;21(16):6405-12.  PMID: 11487664

Brainard GC, Provencio I.  Photoreception for the neurobehavioral effects of light in humans.  Light and Engineering. 2008 Jan;16(1):5-18.

Brainard GC, Sliney D, Hanifin JP, Glickman G, Byrne B, Greeson JM, Jasser S, Gerner E, Rollag MD.  Sensitivity of the human circadian system to short-wavelength (420-nm) light.  J Biol Rhythms. 2008 Oct;23(5):379-86.  PMID: 18838601

Brooks NE, Cadena SM, Vannier E, Cloutier G, Carambula S, Myburgh KH, Roubenoff R, Castaneda-Sceppa C.  Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery.  Muscle Nerve. 2010 Oct 6. [Epub ahead of print] PMID: 20928906

Brooks N, Cloutier GJ, Cadena SM, Layne JE, Nelsen CA, Freed AM, Roubenoff R, Castaneda-Sceppa C.  Resistance training and timed essential amino acids protect against the loss of muscle mass and strength during 28 days of bed rest and energy deficit.  J Appl Physiol. 2008 Jul;105(1):241-8.  PMID: 18483167

Brown EN, Luithardt H.  Statistical model building and model criticism for human circadian data.  J Biol Rhythms. 1999 Dec;14(6):609-16.  PMID: 10643759

Brown EN, Choe Y, Luithardt H, Czeisler CA.  A statistical model of the human core-temperature circadian rhythm.  Am J Physiol Endocrinol Metab. 2000 Sep;279(3):E669-83. PMID: 10950837

Byrne B, Brainard GC.  Seasonal affective disorder and light therapy.  Sleep Medicine Clinics. 2008 Jun;3(2):307-15.  Full article

Cain SW, Dennison CF, Zeitzer JM, Guzik AM, Khalsa SB, Santhi N, Schoen MW, Czeisler CA, Duffy JF.  Sex differences in phase angle of entrainment and melatonin amplitude in humans.  J Biol Rhythms. 2010 Aug;25(4):288-96.  PMID: 20679498

Cajochen C, Foy R, Dijk DJ.  Frontal predominance of relative increase in sleep delta and theta EEG activity after sleep loss in humans.  Sleep Research Online. 1999;2(3):65-9.  PMID: 11382884

Cajochen C, Jewett ME, Dijk DJ.  Human circadian melatonin rhythm phase delay during a fixed sleep-wake schedule interspersed with nights of sleep deprivation.  J Pineal Res. 2003 Oct;35(3):149-57.  PMID: 12932197

Cajochen C, Khalsa SB, Wyatt JK, Czeisler CA, Dijk DJ.  EEG and ocular correlates of circadian melatonin phase and human performance decrements during sleep loss.  Am J Physiol Regul Integr Comp Physiol. 1999 Sep;277(3 Pt 2):R640-9.  PMID: 10484479

Cajochen C, Zeitzer JM, Czeisler CA, Dijk DJ.  Dose-response relationship for light intensity and ocular and electroencephalographic correlates of human alertness.  Behav Brain Res. 2000 Oct;115(1):75-83.  PMID: 10996410

Callini G, Essig SM, Heher DM, Young LR.  Effectiveness of an expert system for astronaut assistance on a sleep experiment.  Aviat Space Environ Med. 2000 Oct;71(10):1023-32.  PMID: 11051309

Chee MW, Tan JC, Zheng H, Parimal S, Weissman DH, Zagorodnov V, Dinges DF.  Lapsing during sleep deprivation is associated with distributed changes in brain activation.  J Neurosci. 2008 May 21;28(21):5519-28.  PMID: 18495886

Cho Y, Kim H, Turner ND, Mann JC, Wei J, Taddeo SS, Davidson LA, Wang N, Vannucci M, Carroll RJ, Chapkin RS, Lupton JR. A chemoprotective fish oil- and pectin-containing diet temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis. J Nutr. [Epub ahead of print] doi:10.3945/jn.110.134973, 2011.

Cohen DA, Wang W, Wyatt JK, Kronauer RE, Dijk DJ, Czeisler CA, Klerman EB.  Uncovering residual effects of chronic sleep loss on human performance.  Sci Transl Med. 2010 Jan 13;2(14):14ra3. 
PMID: 20371466

Cree MG, Paddon-Jones D, Newcomer BR, Ronsen O, Aarsland A, Wolfe RR, Ferrando A.  Twenty-eight-day bed rest with hypercortisolemia induces peripheral insulin resistance and increases intramuscular triglycerides.  Metabolism. 2010 May;59(5):703-10.  PMID: 19919871

Crim KC, Sanders LM, Hong MY, Taddeo S, Turner ND, Chapkin RS, Lupton JR.  Upregulation of p21Waf1/Cip1 expression in vivo by butyrate administration can be chemoprotective or chemopromotive depending on the lipid component of the diet.  Carcinogenesis. 2008 Jul;29(7):1415-20.  PMID: 18567619

Czeisler CA.  Medical and genetic differences in the adverse impact of sleep loss on performance: Ethical considerations for the medical profession.  Trans Am Clin Climatol Assoc. 2009;120:249-85.  PMID: 19768182

Czeisler CA, Brown EN.  Commentary: Models of the effect of light on the human circadian system:  current state of the art.  J Biol Rhythms. 1999 Dec;14(6):538-43.  PMID: 10643751

Czeisler CA, Gooley JJ.  Sleep and circadian rhythms in humans.  Cold Spring Harb Symp Quant Biol.. 2007;72:579-97.  PMID: 18419318

Czeisler CA, Klerman EB.  Circadian and sleep-dependent regulation of hormone release in humans.  Recent Prog Horm Res. 1999;54:97-130; discussion 130-2.  PMID: 10548874

Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk DJ, Kronauer RE.  Stability, precision and near 24-hour period of the human circadian pacemaker.  Science. 1999 Jun 25;284(5423):2177-81.  PMID: 10381883

Davidson AJ, London B, Block GD, Menaker M.  Cardiovascular tissues contain independent circadian clocks.  Clin Exp Hypertens. 2005 Feb-Apr;27(2-3):307-11. PMID: 15835394

Davidson AJ, Poole AS, Yamazaki S, Menaker M.  Is the food-entrainable circadian oscillator in the digestive system?  Genes Brain Behav. 2003 Feb;2(1):32-9.  PMID: 12882317

Davidson AJ, Sellix MT, Daniel J, Yamazaki S, Menaker M, Block GD.  Chronic jet-lag increases mortality in aged mice.  Curr Biol. 2006 Nov 7;16(21):R914-6.  PMID: 17084685

Davidson AJ, Straume M, Block GD, Menaker M. Daily timed meals dissociate circadian rhythms in hepatoma and healthy host liver. Int J Cancer. 2006 Apr 1;118(7):1623-7. PMID: 16231323

Davidson AJ, Tataroglu O, Menaker M.  Circadian effects of timed meals (and other rewards).  Methods Enzymol. 2005;393:509-23.  
PMID: 15817309

Davidson AJ, Yamazaki S, Arble DM, Menaker M, Block GD.  Resetting of central and peripheral circadian oscillators in aged rats.  Neurobiol Aging. 2008 Mar;29(3):471-7.  PMID: 17129640

Dean DA 2nd, Fletcher A, Hursh SR, Klerman EB. Developing mathematical models of neurobehavioral performance for the "real world".   J Biol Rhythms. 2007 Jun;22(3):246-58.  PMID: 17517914

Dean DA 2nd, Forger DB, Klerman EB.  Taking the lag out of jet lag through model-based schedule design.  PLoS Comput Biol. 2009 Jun;5(6):e1000418.  PMID: 19543382 

Dijk DJ.  Circadian variation of EEG power spectra in NREM and REM sleep in humans: dissociation from body temperature.  J Sleep Res. 1999 Sep;8(3):189-95.  PMID: 10476005   

Dijk DJ, Neri DF, Wyatt JK, Ronda JM, Riel E, Ritz-De Cecco A, Hughes RJ, Elliott AR, Prisk GK, West JB, Czeisler CA.  Sleep, performance, circadian rhythms, and light-dark cycles during two space shuttle flights.  Am J Physiol Regul Integr Comp Physiol. 2001 Nov;281(5):R1647-64.  PMID: 11641138

Dinges DF. Critical research issues in development of biomathematical models of fatigue and performance.  Aviat Space Environ Med. 2004 Mar;75(3 Suppl):A181-91.  PMID: 15018283

Dinges DF, Achermann P.  Commentary: future considerations for models of human neurobehavioral function.  J of Biological Rhythms. 1999 Dec;14(6):598-601.  PMID: 10643757

Doran SM, Van Dongen HP, Dinges DF.  Sustained attention performance during sleep deprivation: evidence of state instability.  Arch Ital Biol. 2001 Apr;139(3):253-67.  PMID: 11330205

Duffy JF, Cain SW, Chang AM, Phillips AJ, Münch MY, Gronfier C, Wyatt JK, Dijk DJ, Wright KP Jr, Czeisler CA. Quantification of Behavior Sackler Colloquium: Sex difference in the near-24-hour intrinsic period of the human circadian timing system. Proc Natl Acad Sci U S A., [Epub ahead of print] 10.1073/pnas.1010666108, 2011.

Duffy JF,
Czeisler CA.  Effect of Light on Human Circadian Physiology.  Sleep Med Clin. 2009 Jun;4(2):165-77.  PMID: 20161220

Duffy JF, Rimmer DW, Czeisler CA.  Association of intrinsic circadian period with morningness-eveningness, usual wake time, and circadian phase.  Behav Neurosci. 2001 Aug;115(4):895-9.  PMID: 11508728

Duffy JF, Wright KP Jr.  Entrainment of the human circadian system by light.  J Biol Rhythms. 2005 Aug;20(4):326-38.  PMID: 16077152

Dunlap KL, Reynolds AJ, Tosini G, Kerr WW, Duffy LK. Seasonal and diurnal melatonin production in exercising sled dogs. Comp Biochem Physiol A Mol Integr Physiol. 2007 Aug;147(4):863-7.  PMID: 17379556

Durmer JS, Dinges DF.  Neurocognitive consequences of sleep deprivation.  Semin Neurol. 2005 Mar;25(1):117-29.  PMID: 15798944

Ferrando AA, Paddon-Jones D, Wolfe RR.  Alterations in protein metabolism during space flight and inactivity.  Nutrition. 2002 Oct;18(10):837-41.  PMID: 12361775

Fitts RH, Romatowski JG, Peters JR, Paddon-Jones D, Wolfe RR, Ferrando AA.  The deleterious effects of bed rest on human skeletal muscle fibers are exacerbated by hypercortisolemia and ameliorated by dietary supplementation.  Am J Physiol Cell Physiol. 2007 Jul;293(1):C313-20PMID: 17409123

Forger DB, Jewett ME, Kronauer RE.  A simpler model of the human circadian pacemaker.  J Biol Rhythms. 1999 Dec;14(6):532-7.  PMID: 10643750

Foster RG, Bellingham J.  Inner retinal photoreceptors (IRPs) in mammals and teleost fish.  Photochem Photobiol Sci. 2004 Jun;3(6):617-27.  PMID: 15170494

Foster RG, Wulff K.  The rhythm of rest and excess.  Nat Rev Neurosci. 2005 May;6(5):407-14.  PMID: 15861183

Fucci RL, Gardner J, Hanifin JP, Jasser S, Byrne B, Gerner E, Rollag M, Brainard GC.  Toward optimizing lighting as a countermeasure to sleep and circadian disruption in space flight.  Acta Astronaut. 2005 May-Jun;56(9-12):1017-24.  PMID: 15838948

Fukuhara C, Aguzzi J, Bullock N, Tosini G.  Effect of long-term exposure to constant dim light on the circadian system of rats.  Neurosignals. 2005;14(3):117-25.  PMID: 16088226

Fukuhara C, Dirden JC, Tosini G.  Regulation of period 1 expression in cultured rat pineal.  Neurosignals. 2002 Mar-Apr;11(2):103-14.  PMID: 12077484

Fukuhara C, Liu C, Ivanova TN, Chan GC, Storm DR, Iuvone PM, Tosini G.  Gating of the cAMP signaling cascade and melatonin synthesis by the circadian clock in mammalian retina.  J Neurosci. 2004 Feb 25;24(8):1803-11.  PMID: 14985420

Fukuhara C, Tosini G.  Peripheral circadian oscillators and their rhythmic regulation.  Front Biosci. 2003 May 1;8:d642-51.  PMID: 12700075

Fuller PM, Jones TA, Jones SM, Fuller CA.  Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?  Proc Natl Acad Sci. 2002 Nov 26;99(24):15723-8.  PMID: 12434016

George NI, Lupton JR, Turner ND, Chapkin RS, Davidson LA, Wang N.  Evaluation of fecal mRNA reproducibility via a marginal transformed mixture modeling approach.  BMC Bioinformatics. 2010 Jan 7;11(1):13.  PMID: 20055994

Glickman G, Byrne B, Pineda C, Hauck WW, Brainard GC.  Light therapy for seasonal affective disorder with blue narrow-band light-emitting diodes (LEDs).  Biol Psychiatry. 2006 Mar 15;59(6):502-7.  PMID: 16165105

Glickman G, Hanifin JP, Rollag MD, Wang J, Cooper H, Brainard GC.  Inferior retinal light exposure is more effective than superior retinal exposure in suppressing melatonin in humans.  J Biol Rhythms. 2003 Feb;18(1):71-9.  PMID: 12568246

Glickman G, Levin R, Brainard GC.  Ocular input for human melatonin regulation:  relevance to breast cancer.  Neuroendocrinol Lett. 2002 Jul;23 Suppl 2:17-22.  PMID: 12163843

Goel N, Banks S, Mignot E, Dinges DF.  PER3 polymorphism predicts cumulative sleep homeostatic but not neurobehavioral changes to chronic partial sleep deprivation.  PLoS One. 2009 Jun 11;4(6):e5874.  PMID: 19516903

Gooley JJ, Chamberlain K, Smith KA, Khalsa SBS, Rajaratnam SMW, Van Reen E, Zeitzer JM, Czeisler CA, Lockley SW Exposure to Room Light before Bedtime Suppresses Melatonin Onset and Shortens Melatonin Duration in Humans. J Clin. Endocrinol. Metabl. 2011 96:E463-E472

Gooley JJ, Rajaratnam SM, Brainard GC, Kronauer RE, Czeisler CA, Lockley SW.  Spectral responses of the human circadian system depend on the irradiance and duration of exposure to light.  Sci Transl Med. 2010 May 12;2(31):31ra33. 
PMID: 20463367 

Gordon JA, Alexander EK, Lockley SW, Flynn-Evans E, Venkatan SK, Landrigan CP, Czeisler CA; Harvard Work Hours, Health, and Safety Group (Boston, Massachusetts).  Does simulator-based clinical performance correlate with actual hospital behavior? The effect of extended work hours on patient care provided by medical interns.  Acad Med. 2010 Oct;85(10):1583-8.  PMID: 20881679

Gronfier C, Wright KP Jr, Kronauer RE, Czeisler CA. Entrainment of the human circadian pacemaker to longer-than-24-h days. Proc Natl Acad Sci U S A. 2007 May 22;104(21):9081-6.  PMID: 17502598

Hanifin JP, Brainard GC. Photoreception for circadian, neuroendocrine, and neurobehavioral regulation. J Physiol Anthropol. 2007 Mar;26(2):87-94.  PMID: 17435349

Hanifin JP, Stewart KT, Smith P, Tanner R, Rollag M, Brainard GC.  High-intensity red light suppresses melatonin.  Chronobiol Int. 2006;23(1-2):251-68.  PMID: 16687299

Highstead RG, Tipton KD, Creson DL, Wolfe RR, Ferrando AA.  Incidence of associated events during the performance of invasive procedures in healthy human volunteers.  J Appl Physiol. 2005 Apr;98(4):1202-6.  PMID: 15563628

Hong MY, Bancroft LK, Turner ND, Davidson LA, Murphy ME, Carroll RJ, Chapkin RS, Lupton JR.  Fish oil decreases oxidative DNA damage by enhancing apoptosis in rat colon.  Nutr Cancer. 2005;52(2):166-75.  PMID: 16201848

Hong MY, Chapkin RS, Barhoumi R, Burghardt RC, Turner ND, Henderson CE, Sanders LM, Fan YY, Davidson LA, Murphy ME, Spinka CM, Carroll RJ, Lupton JR.  Fish oil increases mitochondrial phospholipid unsaturation, upregulating reactive oxygen species and apoptosis in rat colonocytes.  Carcinogenesis. 2002 Nov;23(11):1919-25.  PMID: 12419841

Hong MY, Chapkin RS, Davidson LA, Turner ND, Morris JS, Carroll RJ, Lupton JR.  Fish oil enhances targeted apoptosis during colon tumor initiation in part by down regulating bcl-2.  Nutr Cancer. 2003;46(1):44-51.  PMID: 12925303

Hong MY, Turner ND, Carroll RJ, Chapkin RS, Lupton JR.  Differential response to DNA damage may explain different cancer susceptibility between small and large intestine.  Exp Biol Med. 2005 Jul;230(7):464-71.  PMID: 15985621

Horowitz SS, Blanchard J, Morin LP.  Medial vestibular connections with the hypocretin (orexin) system.  J Comp Neurol. 2005 Jun 27;487(2):127-46.  PMID: 15880498

Horowitz SS, Blanchard JH, Morin LP.  Intergeniculate leaflet and ventral lateral geniculate nucleus afferent connections: an anatomical substrate for functional input from the vestibulo-visuomotor system.  J Comp Neurol. 2004 Jun 21;474(2):227-45.  PMID: 15164424 

Hull JT, Wright KP Jr, Czeisler CA.  The influence of subjective alertness and motivation on human performance independent of circadian and homeostatic regulation.  J Biol Rhythms. 2003 Aug;18(4):329-38.  PMID: 12932085

Indic P, Forger DB, St Hilaire MA, Dean DA 2nd, Brown EN, Kronauer RE, Klerman EB, Jewett ME.  Comparison of amplitude recovery dynamics of two limit cycle oscillator models of the human circadian pacemaker.  Chronobiol Int. 2005;22(4):613-29.  PMID: 16147894

Indic P, Gurdziel K, Kronauer RE, Klerman EB.  Development of a two-dimension manifold to represent high dimension mathematical models of the intracellular mammalian circadian clock.  J Biol Rhythms. 2006 Jun;21(3):222-32.  PMID: 16731662

Jasser SA, Hanifin JP, Rollag MD, Brainard GC.  Dim light adaptation attenuates acute melatonin suppression in humans.  J Biol Rhythms. 2006 Oct;21(5):394-404.  PMID: 16998159

Jewett ME, Kronauer RE.  Interactive mathematical models of subjective alertness and cognitive throughput in humans.  J Biol Rhythms. 1999 Dec;14(6):588-97.  PMID: 10643756

Jewett ME, Forger DB, Kronauer RE.  Revised limit cycle oscillator model of human circadian pacemaker.  J Biol Rhythms. 1999 Dec;14(6):493-9.  PMID: 10643746

Jewett ME, Dijk DJ, Kronauer RE, Dinges DF.  Dose-response relationship between sleep duration and human psychomotor vigilance and subjective alertness.  Sleep. 1999 Mar 15;22(2):171-9.  PMID: 10201061

Jewett ME, Wyatt JK, Ritz-De Cecco A, Khalsa SB, Dijk DJ, Czeisler CA.  Time course of sleep inertia dissipation in human performance and alertness.  J Sleep Res. 1999 Mar;8(1):1-8.  PMID: 10188130

Jung CM, Ronda JM, Czeisler CA, Wright Jr KP.  Comparison of sustained attention assessed by auditory and visual psychomotor vigilance tasks prior to and during sleep deprivation.  J Sleep Res. 2010 Aug 31. [Epub ahead of print] PMID: 20819145

Khalsa SB, Jewett ME, Cajochen C, Czeisler CA.  A phase response curve to single bright light pulses in human subjects.  J Physiol. 2003 Jun 15;549(Pt 3):945-52.  PMID: 12717008

Khalsa SBS, Jewett ME, Duffy JF, Czeisler CA.  The timing of the human circadian clock is accurately represented by the core body temperature rhythm following phase shifts to a three-cycle light stimulus near the critical zone.  J Biol Rhythms. 2000 Dec;15(6):524-30.  PMID: 11106069

Klerman EB.  Clinical aspects of human circadian rhythms.  J Biol Rhythms. 2005 Aug;20(4):375-86.  PMID: 16077156

Klerman EB, Jewett ME.  Commentary: Model building, quantitative testing, and model comparison.  Jour Biol Rhythms. 1999 Dec;14(6):621-4.  PMID: 10643761

Klerman EB, Adler GK, Jin M, Maliszewski AM, Brown EN.  A statistical model of diurnal variation in human growth hormone.  Am J Physiol Endocrinol Metab. 2003 Nov;285(5):E1118-26.  PMID: 12888486

Klerman EB, Hilaire M. On mathematical modeling of circadian rhythms, performance, and alertness. J Biol Rhythms. 2007 Apr;22(2):91-102.  PMID: 17440211

Kronauer RE, Forger DB, Jewett ME.  Quantifying human circadian pacemaker response to brief, extended and repeated light stimuli over the phototopic range.  J Biol Rhythms. 1999 Dec;14(6):500-15.  PMID: 10643747

Kronauer RE, Gunzelmann G, Van Dongen HP, Doyle FJ 3rd, Klerman EB. Uncovering physiologic mechanisms of circadian rhythms and sleep/wake regulation through mathematical modeling. J Biol Rhythms. 2007 Jun;22(3):233-45.  PMID: 17517913

Kwak Y, Lundkvist GB, Brask J, Davidson A, Menaker M, Kristensson K, Block GD.  Interferon-gamma alters electrical activity and clock gene expression in suprachiasmatic nucleus neurons.  J Biol Rhythms. 2008 Apr;23(2):150-9.  PMID: 18375864

Landrigan CP, Barger LK, Cade BE, Ayas NT, Czeisler CA.  Interns' compliance with Accreditation Council for Graduate Medical Education work-hour limits.  JAMA. 2006 Sep 6;296(9):1063-70.  PMID: 16954485

Landrigan CP, Czeisler CA, Barger LK, Ayas NT, Rothschild JM, Lockley SW; Harvard Work Hours, Health and Safety Group.  Effective implementation of work-hour limits and systemic improvements.  Jt Comm J Qual Patient Saf. 2007 Nov;33(11 Suppl):19-29.  PMID: 18173163

Landrigan CP, Rothschild JM, Cronin JW, Kaushal R, Burdick E, Katz JT, Lilly CM, Stone PH, Lockley SW, Bates DW, Czeisler CA.  Effect of reducing interns' work hours on serious medical errors in intensive care units.  N Engl J Med. 2004 Oct 28;351(18):1838-48.  PMID: 15509817

Leyk M, Nguyen DV, Attoor SN, Dougherty ER, Turner ND, Bancroft LK, Chapkin RS, Lupton JR, Carroll RJ.  Comparing automatic and manual image processing in FLARE assay analysis for colon carcinogenesis.  Stat Appl Genet Mol Biol. 2005;4:Article5.  PMID: 16646858

Li Y, Wang N, Hong M, Turner ND, Lupton JR, Carroll RJ.  Nonparametric estimation of correlation functions in longitudinal and spatial data, with application to colon carcinogenesis experiments.  Ann Stat. 2007 Aug;35(4):1608-43.  Full article

Lim J, Dinges DF.  A meta-analysis of the impact of short-term sleep deprivation on cognitive variables.  Psychol Bull.  2010 May;136(3):375-89.  PMID: 20438143

Lim J, Dinges DF.  Sleep deprivation and vigilant attention.  Ann NY Acad Sci. 2008; 1129:305-22.  PMID: 18591490

Lim J, Tan JC, Parimal S, Dinges DF, Chee MW.  Sleep deprivation impairs object-selective attention: A view from the ventral visual cortex.  PLoS One. 2010 Feb 5;5(2):e9087.  PMID: 20140099

Liu LY, Wang N, Lupton JR, Turner ND, Chapkin RS, Davidson LA.  A two-stage normalization method for partially degraded mRNA microarray data.  Bioinformatics 2005 Nov 1;21(21):4000-6.  PMID: 16150808

Lockley SW.  Spectral sensitivity of circadian, neuroendocrine and neurobehavioral effects of light.  J Human-Environ Sys. 2008;11(1):43-49.  Full article

Lockley SW, Barger LK, Ayas NT, Rothschild JM, Czeisler CA, Landrigan CP; Harvard Work Hours, Health and Safety Group.  Effects of health care provider work hours and sleep deprivation on safety and performance.  Jt Comm J Qual Patient Saf. 2007 Nov;33(11 Suppl):7-18.  PMID: 18173162

Lockley SW, Cronin JW, Evans EE, Cade BE, Lee CJ, Landrigan CP, Rothschild JM, Katz JT, Lilly CM, Stone PH, Aeschbach D, Czeisler CA; Harvard Work Hours, Health and Safety Group.  Effect of reducing interns' weekly work hours on sleep and attentional failures.  N Engl J Med. 2004 Oct 28;351(18):1829-37.  PMID: 15509816

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Lockley SW, Landrigan CP, Barger LK, Czeisler CA; Harvard Work Hours Health and Safety Group.  When policy meets physiology: The challenge of reducing resident work hours.  Clin Orthop Relat Res. 2006 Aug;449:116-27.  PMID: 16770285

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Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM.  Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.  J Am Coll Cardiol. 2004 Feb 18;43(4):678-83.  PMID: 14975482

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Mollicone DJ, Van Dongen HPA, Dinges DF.  Optimizing sleep/wake schedules in space: Sleep during chronic nocturnal sleep restriction with and without diurnal naps.  Acta Astronaut. 2007 Feb-Apr;60(4-7):354-61.  Full article

Mollicone DJ, Van Dongen HP, Rogers NL, Dinges DF.  Response surface mapping of neurobehavioral performance: Testing the feasibility of split sleep schedules for space operations.  Acta Astronaut. 2008 Oct-Nov;63(7-10):833-40.  PMID: 19194521 

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Nguyen J, Wright KP Jr. Influence of weeks of circadian misalignment on leptin levels. Nature and Science of Sleep. 2009 Dec;2010(2):9-18. Full article

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Paddon-Jones D, Sheffield-Moore M, Cree MG, Hewlings SJ, Aarsland A, Wolfe RR, Ferrando AA.  Atrophy and impaired muscle protein synthesis during prolonged inactivity and stress.  J Clin Endocrinol Metab. 2006 Dec;91(12):4836-41.  PMID: 16984982

Paddon-Jones D, Sheffield-Moore M, Creson DL, Sanford AP, Wolf SE, Wolfe RR, Ferrando AA.  Hypercortisolemia alters muscle protein anabolism following ingestion of essential amino acids.  Am J Physiol Endocrinol Metab. 2003 May;284(5):E946-53.  PMID: 12569085

Paddon-Jones D, Sheffield-Moore M, Urban RJ, Aarsland A, Wolfe RR, Ferrando AA.  The catabolic effects of prolonged inactivity and acute hypercortisolemia are offset by dietary supplementation.  J Clin Endocrinol Metab. 2005 Mar;90(3):1453-9.  PMID: 15598679

Paddon-Jones D, Sheffield-Moore M, Urban RJ, Sanford AP, Aarsland A, Wolfe RR, Ferrando AA.  Essential amino acid and carbohydrate supplementation ameliorates muscle protein loss in humans during 28 days bedrest.  J Clin Endocrinol Metab. 2004 Sep;89(9):4351-8.  PMID: 15356032

Paddon-Jones D, Sheffield-Moore M, Zhang XJ, Volpi E, Wolf SE, Aarsland A, Ferrando AA, Wolfe RR.  Amino acid ingestion improves muscle protein synthesis in the young and elderly.  Am J Physiol Endocrinol Metab. 2004 Mar;286(3):E321-8.  PMID: 14583440

Paddon-Jones D, Wolfe RR, Ferrando AA.  Amino acid supplementation for reversing bed rest and steroid myopathies.  J Nutr. 2005 Jul;135(7):1809S-1812S.  PMID: 15987870

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Pechacek CS, Andersen M, Lockley SW.  Preliminary method for prospective analysis of the circadian efficacy of (Day)light with applications to healthcare architecture.  LEUKOS. 2008;5(1):1-26.  Full article

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Phillips AJ, Chen PY, Robinson PA.  Probing the mechanisms of chronotype using quantitative modeling.  J Biol Rhythms. 2010 Jun;25(3):217-27.  PMID: 20484693

Phillips AJ, Robinson PA, Kedziora DJ, Abeysuriya RG.  Mammalian sleep dynamics: how diverse features arise from a common physiological framework.  PLoS Comput Biol. 2010 Jun 24;6(6):e1000826.  PMID: 20585613

Phillips AJ, Czeisler CA, Klerman EB. Revisiting Spontaneous Internal Desynchrony Using a Quantitative Model of Sleep Physiology. J Biol Rhythms, 26: 441, 2011, [Epub ahead of print] doi: 10.1177/0748730411414163, 2011.

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Rogers NL, Dorrian J, Dinges DF.  Sleep, waking and neurobehavioural performance.  Front Biosci. 2003 Sep 1;8:s1056-67.  PMID: 12957855

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Salem JE, Stanley WC, Cabrera ME.  Computational studies of the effects of myocardial blood flow reductions on cardiac metabolism.  Biomed Eng Online. 2004 Jun 2;3(1):15.  PMID: 15175110

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Sanders LM, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Wang N, Spinka CM, Carroll RJ, Turner ND, Chapkin RS, Lupton JR.  An increase in reactive oxygen species by dietary fish oil coupled with the attenuation of antioxidant defenses by dietary pectin enhances rat colonocyte apoptosis.  J Nutr. 2004 Dec;134(12):3233-8.  PMID: 15570018

Santhi N, Aeschbach D, Horowitz TS, Czeisler CA.  The impact of sleep timing and bright light exposure on attentional impairment during night work.  J Biol Rhythms. 2008 Aug;23(4):341-52.  PMID: 18663241

Santhi N, Horowitz TS, Duffy JF, Czeisler CA.  Acute sleep deprivation and circadian misalignment associated with transition onto the first night of work impairs visual selective attention.  PLoS ONE. 2007 Nov 28;2(11):e1233.  PMID: 18043740

Scadeng M, Rossiter HB, Dubowitz DJ, Breen EC. High-resolution three-dimensional magnetic resonance imaging of mouse lung in situ. Invest Radiol. 2007 Jan;42(1):50-7.  PMID: 17213749

Scheer FA, Wright KP Jr, Kronauer RE, Czeisler CA.  Plasticity of the intrinsic period of the human circadian timing system.  PLoS ONE. 2007 Aug 8;2(8):e721.  PMID: 17684566

Sekaran S, Lupi D, Jones SL, Sheely CJ, Hattar S, Yau KW, Lucas RJ, Foster RG, Hankins MW.  Melanopsin-dependent photoreception provides earliest light detection in the mammalian retina.  Curr Biol. 2005 Jun 21;15(12):1099-107.  PMID: 15964274

Sellix MT, Yoshikawa T, Menaker M.  A circadian egg timer gates ovulation.  Curr Biol. 2010 Mar 23;20(6):R266-7.  PMID: 20334830

Simpson NS, Banks S, Arroyo S, Dinges DF.  Effects of sleep restriction on adiponectin levels in healthy men and women.  Physiol Behav. 2010 Aug 17. [Epub ahead of print] PMID: 20723551

Smith KA, Schoen MW, Czeisler CA.  Adaptation of human pineal melatonin suppression by recent photic history.  J Clin Endocrinol Metab. 2004 Jul;89(7):3610-4.  PMID: 15240654

St Hilaire MA, Gronfier C, Zeitzer JM, Klerman EB.  A physiologically based mathematical model of melatonin including ocular light suppression and interactions with the circadian pacemaker.  J Pineal Res. 2007 Oct;43(3):294-304.  PMID: 17803528

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Tataroglu O, Davidson AJ, Benvenuto LJ, Menaker M.  The methamphetamine-sensitive circadian oscillator (MASCO) in mice.  J Biol Rhythms. 2006 Jun;21(3):185-94.  PMID: 16731658

Thompson S, Lupi D, Hankins MW, Peirson SN, Foster RG.  The effects of rod and cone loss on the photic regulation of locomotor activity and heart rate.  Eur J Neurosci. 2008 Aug;28(4):724-9.  PMID: 18702692

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Tosini G, Davidson AJ, Fukuhara C, Kasamatsu M, Castanon-Cervantes O.  Localization of a circadian clock in mammalian photoreceptors.  FASEB J. 2007 Dec;21(14):3866-71.  PMID: 17621597

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Vanamala J, Glagolenko A, Yang P, Carroll RJ, Murphy ME, Newman RA, Ford JR, Braby LA, Chapkin RS, Turner ND, Lupton JR.  Dietary fish oil and pectin enhance colonocyte apoptosis in part through suppression of PPARdelta/PGE2 and elevation of PGE3.  Carcinogenesis. 2008 Apr;29(4):790-6.  PMID: 18024478

Van Dongen HP, Dinges DF.  Investigating the interaction between the homeostatic and circadian processes of sleep-wake regulation for the prediction of waking neurobehavioural performance.  J Sleep Res. 2003 Sep;12(3):181-7.  PMID: 12941057

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Van Dongen HP, Maislin G, Dinges DF.  Dealing with inter-individual differences in the temporal dynamics of fatigue and performance: importance and techniques.  Aviat Space Environ Med 75. 2004 Mar;75(3 Suppl):A147-54.  PMID: 15018277

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Van Dongen HP, Rogers NL, Dinges DF.  Sleep debt: theoretical and empiral issues.  Sleep and Biological Rhythms 4:4-12, 2003. 

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Wright KP Jr, Hull JT, Czeisler CA.  Relationship between alertness, performance, and body temperature in humans.  Am J Physiol Regul Integr Comp Physiol. 2002 Dec;283(6):R1370-7.  PMID: 12388468

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