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DNA sequencing identifies viruses in study subjects living under
isolation conditions.
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Deliverables for Exploration and Earth Applications
The Immunology, Infection and Hematology Team is identifying practical countermeasures for the
adverse effects of space flight on the normal functioning of the human immune and blood-forming
systems.
Anticipated deliverables include:
- Recommendations for dietary supplements to prevent radiation-induced myeloid malignancy;
- Managing stem cell damage caused by space flight through replacement of bone marrow stem
cells postflight;
- Diminishing latent virus reactivation through pharmacologic intervention;
- Methods to block and counter programmed cell death to prevent lymphoid loss and/or
dysfunction during radiation exposure, and;
- Understanding the effects of long-term bed rest on immune function.
Earth Applications
Many of the countermeasures for human health in space have future applications for Earth use. In
the area of immunity, these include:
- Countermeasures for the adverse effects of radiation are applicable to people exposed to
higher-than-normal levels of radiation, such as occupational exposures, airline crews and persons
undergoing interventional radiology as a medical procedure;
- Knowledge of virus reactivation can be used with patients suffering serious, sometimes
life-threatening consequences resulting from immunosuppression, and;
- The study of bed rest and the immune response can aid treatment of elderly or bed-ridden
hospital patients who develop infectious complications.
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